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CZ Biohub

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Major milestones over time

AINews: 10% worse, 100x cheaper, 10000x faster: Why Simulation is taking over

According to Latent Space, since 2022, components of the AI pipeline have been shifting from human-made to model-made, each flip starting with a 'patient zero' at a frontier lab. This trend is characterized as simulation: slightly worse (10%), but 100x cheaper and 10,000x faster. Stage 1 (2022): Reward signal went synthetic with InstructGPT's reward model, followed by Constitutional AI and RLAIF, where AI critiques i

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Genome-Wide CRISPR Screen Reveals New Psoriasis Targets

Biohub researchers performed what they believe is the first genome-wide CRISPR study of primary human adult skin cells, then used an AI model to mine the results for overlooked drug targets for psoriasis. They found an unlikely candidate: the receptor for oxytocin, a hormone involved in childbirth, and sometimes called the “love hormone” for its additional role in social bonding. As reported in Nature Communications,

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CZ Biohub releases “ESM Atlas” with 1.1 billion ESMFold2-predicted protein structures, claiming to surpass AlphaFold

A claim has emerged that a new protein structure prediction artificial intelligence (AI) model surpasses the performance of Google DeepMind’s AlphaFold, which was developed by DeepMind and even led to the 2024 Nobel Prize in Chemistry. Experts are divided between seeing it as an important new resource for protein structure prediction and expressing doubts about its performance. According to a report in the internatio

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Biohub Releases a World Model of Protein Biology

REDWOOD CITY, Calif., May 27, 2026 – Biohub today announced the release of a world model of protein biology: a scientific engine for prediction, design, and discovery that can map proteins across the tree of life, predict their structures, and design new protein binders that function in laboratory experiments. Proteins are the machinery of life. Nearly every function of the human body depends on them. They are among

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