Arc Institute

Google DeepMind watermarks AI-designed proteins, and the first binders still bind Google DeepMind has taken its SynthID watermark into biology, and says the first watermarked protein binders still bind. In wet-lab testing against three target proteins, VEGF-A, the SARS-CoV-2 spike protein RBD and PD-L1, the watermarked designs “matched the hit rate, binding affinity, and natural sequence diversity of unwatermarked ve

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Radical Numerics co-founder Eric Nguyen discusses genomic language models and biosecurity. He helped develop Evo and Evo 2; a separate Arc/Stanford team later used those models to generate and synthesize functional bacteriophage genomes. The interview distinguishes three sequence scales: an average human gene is about 60K, long genes can reach 2.3M, and the whole human genome is around 3B. Nguyen argues that models w

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Arc Institute’s Patrick Hsu on Building an App Store for Biology with AI Patrick Hsu, co-founder of Arc Institute, discusses the opportunities for AI in biology beyond just drug development, and how Evo 2, their new biology foundation model, is enabling a broad ecosystem of applications. Evo 2 was trained on a vast dataset of genomic data to learn evolutionary patterns that would have taken years to find; as a result

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Anthropic updated its Fable 5 biology safeguards on August 7, the same day researchers from Stanford and the Arc Institute published a paper in Science demonstrating that their Evo 1 and Evo 2 models can design fully functional viral genomes. The timing is not coincidental. The question Anthropic is answering is not whether AI can do biology — Stanford just proved it can — but who gets to control the terms of access.

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“The future of biology is programmable.” To give you a sense of how important this topic is, Patrick Hsu is the first guest we’ve had back to Ground Truths since the podcast began a few years ago. Nearly 2 years ago we spoke about digital biology but so much has happened since to help unravel the complexities in the language of life. Patrick is a co-founder and core investigator at the Arc Institute . His work is at

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