Ensuring multiomics data reproducibility for artificial intelligence with reference materials as a common calibrator

Summary

Nature Biotechnology, Published online: 01 September 2026; doi:10.1038/s41587-026-03267-1 Reference materials should be adopted as a common calibrator for multiomics measurement and co‑profiled with study samples. Multiomics results should be reported as sample‑to‑reference ratios so that they are reproducible and suitable for artificial intelligence tools.